Endocrine Abstracts

Introduction: The most common cause of primary hyperparathyroidism is parathyroid adenoma. Unfortunately, between 11 and 22% of these adenomas are located in ectopic positions. In this report, we describe a case diagnosed in our department with symptomatic primary hyperparathyroidism due to an ectopic parathyroid adenoma localized in thymus.Case presentation: A 21-year-old woman was referred to our clinic for investigations, due to multiples osteoclastom...

Introduction: Turner syndrome is a common cause of dwarfism and hypogonadism as is pituitary failure. However the association of the two is rarely thought and reported in the literature. We present two cases of women with hypogonadism diagnosed with Turner syndrome with various degrees of pituitary insuficiency.Case report: The first case presented at 16 years with secondary amenorrhea and showed slightly disharmonic dwarfism. A hypogonadotropic hypogona...

Background: Idiopathic scoliosis is a pathological entity of unknown etiology, characterized by a three-dimensional deformity of the spine and a low bone mass. The exact mechanism of bone loss in idiopathic scoliosis is unknown yet. However is well known that RANKL is a potent stimulator of bone resorption by binding receptor activator of nuclear factor-kB (RANK) in the osteoclasts cell membrane. OPG is a decoy receptor for RANKL, which interferes with RANKL/RANK binding and i...

Introduction: Pheochromocytoma and paraganglioma are catecholamine secreting tumours. Malignancy is uncommon (approximately 10% for pheochromocytoma and 20% for paraganglioma) and surgery, when possible, is the first line treatment. However, the prognosis is poor because of frequent local recurrence and/or metastases and the lack of specific chemotherapeutic agents. CASE-REPORT: We present the case of a 60 years-old man who, at the age of 48, was diagnosed with paraganglioma. ...

Background: ER-α gene (ESR1) polymorphisms have been associated with a variety of disorders including human infertility. In this study, we examined two polymorphisms of the estrogen receptor α (ESR1) gene, IVS-1 −397 T/C (dbSNP: rs2234693) and IVS-1 −351 A/G (dbSNP: rs9340799) in a sample of healthy women of reproductive age to determine whether are associated with hormonal levels for a better understanding of its biological actions in human development, ...

Adolescent idiopathic scoliosis (IS) represents an evolutive disease that occurs in puberty and progresses till the skeletal maturation. The neuroendocrine hypothesis involving a melatonin deficiency as the source for IS is one of the proposed causes of this plurifactorial disease.Objective: To investigate the hormonal changes of both the gonadal and growth axis and circadian rhythmicity in subjects with adolescent idiopathic scoliosis compared to age ma...

Objective: To explore if the polymorphisms of the estrogen receptor alpha gene, XbaI (IVS1-351 A/G) and PvuII (IVS1-397 T/C) are associated with age-dependent changes in hormone levels for a better understanding of the biological actions of estrogens.Subjects and methods: Subjects, both genders aged between 20 and 80 years were classified into two groups: reproductive age (1) and over 55 years (2). The study received the Ethical Committee approval. Morni...

Patient DE, a 49-year-old woman, was operated in 2005 for two giant-cell tumours of the mandible, and in 2008 for another tumour with the same localisation and histology. Inferior cervical ultrasound after the second surgery revealed a parathyroid adenoma of 20×27×15 mm behind the lower pole of the right thyroid lobe, confirmed by Tc tetrofosmin scintigraphy. The patient had metabolic features suggestive for primary hyperparathyroidism: calcium – 10.9 mg/dl (nor...

Objective: The aim of this study is the characterizing of genetic variation in PvuII and XbaI polymorphisms of the ESR1 gene associated with age-dependent endocrine, metabolic and cognitive changes in a representative sample of Romanian population stratified by age and sex.Subjects and methods: Subjects, both genders aged between 20 and 80 yr were assigned to three lots 1) 177 subjects aged 55–80 years with moderately cognitive impairment (MCI) (MMS...

IntroductionOncocytic neoplasms arising in adrenal tissue are extremely rare with nearly 150 cases being reported in literature. They are mostly nonfunctioning benign tumors, incidentally discovered, but 20% of them demonstrate elements of malignancy and up to 30% appear to affect hormone production.Case reportA 35 years old female with primary amenorrhea, diagnosed with Congenital Adrenal Hyperplasia due to ...